• PMRT is given to the patient one fraction per day

  2018-11-05

  

  PMRT is given to the patient one fraction per day and 5 fractions per week. It usually takes 5 to 6weeks to complete a course of treatment. The treatment places heavy burdens on not just the patients, but also their families and the society; inconveniences that include the daily commutes for treatme

• br Introduction Core binding factor CBF is a heterodimeric

  2018-11-05

  

  Introduction Core binding factor (CBF) is a heterodimeric transcription factor composed of a DNA-binding RUNX subunit (encoded by one of three genes: RUNX1, RUNX2, or RUNX3) and a non-DNA-binding CBFβ subunit which increases the affinity of RUNX proteins for DNA. All three RUNX proteins as well a

• Selection of lead components for further pre clinical testin

  2018-11-05

  

  Selection of ‘lead’ components for further (pre)clinical testing usually occurs on the basis of production yield, affinity and specificity, which should always be re-evaluated in their (radionuclide) labeled format. When internalization in cell line models is established, final validation is done in

• A striking challenge in studying Alzheimer s

  2018-11-05

  

  A striking challenge in studying Alzheimer\'s disease is the use of appropriate animal models. Since Aβ peptides derived from murine APP do not lead to neurodegeneration, almost all animal studies are based on humanized mice overexpressing human APP. Moreover, the mutated APP variant inserted in the

• This study has limitations First the four

  2018-11-05

  

  This study has limitations. First, the four studies were designed independently and involved different methods for recording toxicity. Endpoints needed harmonizing and the approach might be sub-optimal, but serves as a useful guide for future radiogenomics studies involving multiple cohorts. Althoug

• One thing that we learned in the presented ZIKV vaccine

  2018-11-05

  

  One thing that we learned in the presented ZIKV vaccine studies is that the yield of production of the ZIKV envelope E subunit protein was very low in the current format. This finding, also confirmed by a recently published ZIKV vaccine study (Larocca et al., 2016), is similar to what was previously

• Antiretroviral drugs have also been

  2018-11-05

  

  Antiretroviral drugs have also been a focus of attention for this purpose. A differential impact of drug ion channels and individual drugs has been the hypothesis for some analysis of randomized clinical trials. Information on the impact of different ART regimens on inflammatory biomarkers linked wi

• Helminth immunotherapy is also being

  2018-11-05

  

  Helminth immunotherapy is also being evaluated as a therapy for MS, with varying success. So far, clinical trials with TSO in the context of MS have demonstrated modest to no clinical improvement (Wolff et al., 2012). However, in a prospective study where MS patients were enrolled during remission,

• Ependymal cell derived astrocytes are located at

  2018-11-05

  

  Ependymal cell-derived astrocytes are located at the core of the lesion site, while resident astrocytes proliferate and are recruited at the border of the lesion site after spinal cord injury (Barnabe-Heider and Frisen, 2008; Burda and Sofroniew, 2014). It was demonstrated that ageing changes the as

• br Conflict of interest br Contribution details br Acknowled

  2018-11-05

  

  Conflict of interest Contribution details Acknowledgement This study was supported by a financial grant from Swami Rama Himalayan University. We are also thankful to Dr. Judith Owens to allow us to use the Hindi version of CSHQ. Introduction Although considered the gold standard method

• DMXAA br Conclusion We designed and manufactured a portable

  2018-11-05

  

  Conclusion We designed and manufactured a portable smartphone holder and DMXAA LFA strip to produce a smartphone-based measurement system. Salivary cortisol concentration serves as a biomarker of psychological stress. Because physiological cortisol is secreted in a circadian rhythmic manner, the

• Our results agree with the strategy of

  2018-11-03

  

  Our results agree with the strategy of shortening the duration of dual NS5B/NS5A combined therapy to 8weeks, but based on an on-treatment response predictor rather than a baseline variable. This supports the findings of many other studies for the validity of early on-treatment response kinetics as a

• Findings from the most recent Global Burden of

  2018-11-03

  

  Findings from the most recent Global Burden of Disease study, published in October 2016 in , show that in 2015, the mean life expectancy worldwide had reached roughly 72years. This is an increase of 10years since 2000, largely attributed to improvements in childbirth-associated and infant mortality,

• br Data This data article presents the protein

  2018-11-03

  

  Data This data article presents the protein level of HO-1 (Fig. 1) and CD200 (Fig. 2) secreted by BM-MSCs, WJ-MSCs and AT-MSCs in the absence (constitutive) or in the presence of activated T-cells (co-culture). Experimental design, materials and methods Acknowledgements We gratefully ackno

• br Acknowledgements This work is

  2018-11-03

  

  Acknowledgements This work is supported by National Natural Science Fund of China, China (Grant no. 61375079). Data Data shared in this article concern the validation of a model for evaluating the performances of a post-combustion CO2 capture membrane system. Data consist of molar fractions o

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