• A niche is defined as

  2018-10-20

  

  A niche is defined as a microenvironment that maintains stem protease inhibitors through growth factors, cell surface proteins and extracellular matrices (ECMs), and is identified in some organs such as the intestine, brain, skeletal muscle, skin and testis (Chen and Chuong, 2012; Gattazzo et al.,

• These results with fresh non fractionated

  2018-10-20

  

  These results with fresh, non-fractionated, not culture-expanded, adipose tissue-derived SVF are comparable with other two previously reported clinical series, using cultured adipose-derived ADSCs with controlled cell doses. The adipose tissue contains large populations of mesenchymal Anti-infection

• SATB acts as a master regulator

  2018-10-20

  

  SATB2 acts as a master regulator by binding to genes which regulate embryonic development, cell differentiation, pluripotency, and cell survival (Ordonez, 2014; Rosenfeld et al., 2009; Zhao et al., 2014). We have discovered the SATB2 leukotriene receptor antagonists in the promoters of c-Myc, Nanog,

• In addition we detected differences between

  2018-10-20

  

  In addition, we detected differences between PMD1 and PMD2 cells. The differences of susceptibility to ER stresses and the thickness of the myelin sheath were consistent with the different levels of clinical severity of the two patients. The correlations between different clinical severity, differen

• br Results br Discussion Because of their

  2018-10-20

  

  Results Discussion Because of their robust immunomodulatory properties, hBMSCs represent a promising source of adult stem caffeic acid for tissue repair and treatment of many immune disorders (Bernardo and Fibbe, 2012, 2013; García-Castro et al., 2008). hBMSCs have the capacity to home to sit

• Transforming growth factor TGF signaling is

  2018-10-20

  

  Transforming growth factor β (TGF-β) signaling is closely related to DNA damage repair regulation (Mitra et al., 2013). Studies have shown that TGF-β signaling can suppress BRCA1-dependent repair of DSBs (Dubrovska et al., 2005). Activin A, a member of the TGF-β superfamily of cytokines, interacts w

• br Introduction Advances in stem cell

  2018-10-20

  

  Introduction Advances in stem-cell-based therapies may help overcome CNS disorders such as spinal cord injury (SCI). Transplantation of neural stem/progenitor alpha adrenergic blockers (NS/PCs) has yielded beneficial effects and improved functional recovery in SCI animal models (Cummings et al.,

• Introduction The p functions are ubiquitously altered in

  2018-10-20

  

  Introduction The p53 functions are ubiquitously altered in cancer cells by mutations/perturbation of its signaling pathways, and loss of p53 activity is a prerequisite for cancer development. Mutant p53 is thought to play a pivotal role in promoting invasion, favoring cancer cell exit from the prim

• br Results br Discussion In the two dry AMD patients

  2018-10-20

  

  Results Discussion In the two dry AMD patients and one SMD patient, increasing subretinal pigmentation developed at the hESC-RPE cell injection site as has been noted previously (Schwartz et al., 2012, 2015). In the second dry AMD patient and the second SMD patient, multiple spots of increased

• From previous studies we know that cells above the bulge

  2018-10-20

  

  From previous studies we know that cells above the bulge that are Sca-1 and CD34 negative also possess stem cell properties and that these stem cells are not label retaining cells, but relatively active in alkaline phosphatase inhibitor (Jensen et al., 2008). This suggests that LRCs primarily refle

• CXCR is a widely expressed chemokine

  2018-10-20

  

  CXCR4 is a widely expressed chemokine receptor that is essential for development, hematopoiesis, organogenesis, and vascularization (Busillo and Benovic, 2007). The CXCR4/SDF-1 axis is important in cardiac development as evidenced by the observed cardiac phenotype in knockout transgenic strains (Nag

• br Introduction The adult prostate gland contains

  2018-10-20

  

  Introduction The adult prostate gland contains a simple columnar epithelium composed of luminal secretory and underlying basal npy receptor with a scarce neuroendocrine cell component. These epithelial cells are derived from a rare, relatively quiescent stem cell population that maintains glandul

• In the dermis the glial P NGFR positive BC derivatives

  2018-10-20

  

  In the dermis, the glial P75NGFR-positive BC derivatives also include a neurogenic and gliogenic stem-like cell population. Multipotent stem-like cell populations have been described previously in the adult trunk skin, associated with the glial and melanocyte lineages and derived from the NC (Wong e

• Given that a global effort has

  2018-10-20

  

  Given that a global effort has been initiated to develop donor banks of human leukocyte antigen (HLA)-matched iPSC banks that will serve as an extensive library for selecting close to optimal matches for patients (Turner et al., 2013; Fairchild 2015; Solomon et al., 2015), it is clear that the need

• Because Q SA and Q SC represent an

  2018-10-20

  

  Because Q3SA and Q3SC represent an isogenic pair of iPSC lines from the same individual but with contrasting ATM genotypes (ATM−/− versus ATM+/−, respectively), we examined gene expression differences using RNA sequencing (RNA-seq), evaluating matches at the transcript level. Relatively few mRNAs we

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