• If the lack of specificity and

  2025-01-09

  

  If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it Kinase activity modulator may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic interventions

• If the lack of specificity and

  2025-01-09

  

  If the lack of specificity and the high pleiotropy may represent a problem in view of the potential chemotherapeutic features of autophagy-inducing agents, it proanthocyanidins supplements may switch into an advantage in the case of chemopreventive strategies. In fact, as non-pharmacologic interven

• Although plant Aurora kinases can be clearly grouped into

  2025-01-09

  

  Although plant Aurora kinases can be clearly grouped into functional clades, the roles of the respective clades does not seem to be evolutionarily conserved. AtAurora 1 labels kinetochore microtubules [19], similarly to mammalian Aurora A, while its targeting to the cell plate resembles features of

• The tumor suppressor function of LOX in normal prostate epit

  2025-01-09

  

  The tumor-suppressor function of 15-LOX-2 in normal prostate epithelial cells may be explained by the induction of replicative senescence [14,15]. Thus, 15-LOX-2 is overexpressed in age-dependent prostatic hyperplasia, but cell senescence may hinder progression to malignant transformation. Notwithst

• br Interaction between ASK and TRX Thioredoxins are small kD

  2025-01-09

  

  Interaction between ASK1 and TRX Thioredoxins are small (∼12kDa) dithiol oxidoreductases ubiquitously expressed in species ranging from plants to archaea and mammals. They perform various biological functions, such as reducing protein disulfide bonds, supplying reducing equivalents to redox RNA f

• br Asthma The chronic airway

  2025-01-09

  

  Asthma The chronic airway inflammatory disease progesterone cream is associated with enhanced levels of exhaled NO generated by iNOS in the airway epithelium [12]. In asthmatic patients local and systemic changes in iNOS, peroxynitrite, arginase, ADMA and arginine levels have been observed and a

• Kudzu root extract Furthermore because most of foods and bev

  2025-01-09

  

  Furthermore, because most of foods and beverages have been consumed after processing, researchers have focused on the effects of processing (e.g. blanching, cooking, drying, cooling, freezing, high-pressure treatment, pulsed electric field) on total antioxidant capacity of foods. In general, there w

• br Experimental section br Acknowledgment S B T is grateful

  2025-01-09

  

  Experimental section Acknowledgment S.B.T. is grateful to the Deutsche Forschungsgemeinschaft (DFG), the Wilhelm Sander-Stiftung and Interdisciplinary Center for Molecular Materials (ICMM) for generous research support. M.M. greatly acknowledges the experimental support and the scientific cont

• icilin Through an extensive SAR optimization campaign

  2025-01-09

  

  Through an extensive SAR optimization campaign with the 4-((2-hydroxy-3-methoxybenzyl)amino)-benzenesulfonamide-based scaffold researchers have developed ML355 ((N-benzo[d]thiazol-2-yl)-4((2-hydroxy-3 methoxybenzyl)amino)benzenesulfonamide) [5]. ML355 is a nonreductive, noncompetitive, reversible 12

• br Conclusions Several lines of evidence have

  2025-01-08

  

  Conclusions Several lines of evidence have been established, which support the adenosine kinase hypothesis of epileptogenesis, which is based on a sequence of events leading from acute silodosin 8 mg injury to initial downregulation of ADK, rise in extracellular adenosine, changes in astrocytic

• br Introduction Adenosine deaminase ADA also known as adenos

  2025-01-08

  

  Introduction Adenosine deaminase (ADA), also known as adenosine aminohydrolase, is a key enzyme involved in the purine metabolism that converts adenosine to inosine irreversibly (Lupidi et al., 1997). It is a zinc containing metalloenzyme present in both prokaryotes and eukaryotes. In humans ADA

• br Regulation of V ATPase assembly in response

  2025-01-08

  

  Regulation of V-ATPase assembly in response to changes in amino UNC669 levels A central regulator of cell growth and metabolism is mTORC1 [38]. mTORC1 integrates signals from nutrient availability and growth factor receptors to control such processes as protein and lipid synthesis and autophagy.

• In PMCA Mg favors the

  2025-01-08

  

  In PMCA, Mg2+ favors the conversion E1P → E2P [13] and, as in SERCA [11], it accelerates the phosphorylation displacing the E1–E2 equilibrium towards E1. In SERCA, Sørensen et al. [41], proposed that ATP reacts by an associative mechanism mediated by two Mg2+ ions to form an aspartyl-phosphorylated

• Difopein In a recent issue of Minokoshi

  2025-01-07

  

  In a recent issue of , Minokoshi and colleagues have added more light to our understanding of the role of hypothalamic AMPK in the regulation of energy balance. Previous seminal work from the same group suggested that AMPK in the PVH might be involved in the modulation of feeding . Here, they show

• br Concluding Remarks and Future Perspectives While

  2025-01-07

  

  Concluding Remarks and Future Perspectives While postmortem human Phosphate determination assay material is relatively sparse and has inherent limitations as discussed above, additional investigations could benefit from analysis of in vitro cellular models to corroborate findings in patient mater

15972 records 27/1065 page Previous Next First page 上5页 2627282930 下5页 Last page