• TRPM channel has been implicated in cell survival and

  2018-11-12

  

  TRPM7 channel has been implicated in cell survival and proliferation. In zebra fish, TRPM7 knockouts showed several development defects in skeletal muscle and growth retardation (Elizondo et al., 2005). TRPM7 was also reported to regulate cell migration (Wei et al., 2009). Knocking down TRPM7 in DT-

• Both Brat and Mei P belong to the Trim

  2018-11-12

  

  Both Brat and Mei-P26 belong to the Trim-NHL family of proteins, which have conserved functions in stem cell lineages from C. elegans to mouse (for review, see Wulczyn et al., 2010). Proteins within this family are potential E3 ubiquitin ligases and can act by either activating or antagonizing the m

• br Results br Discussion In the

  2018-11-12

  

  Results Discussion In the field of stem cell research, the demand for standardized media is rising, allowing for better reproducibility of results and thereby deepening our knowledge of the pathways regulating their maintenance and differentiation. Here, we set out to determine the minimum req

• Thus the persistent muscle expression

  2018-11-12

  

  Thus, the persistent muscle expression of full length dystrophin remains difficult to achieve currently. Since the discovery of satellite stem px12 and the difficulties met in maintaining their differentiation potential during in vitro culture, several promising alternative candidates for DMD cell t

• Pluripotency tests included flow cytometry analysis of prote

  2018-11-12

  

  Pluripotency tests included flow cytometry analysis of protein stem cell markers SSEA3, SSEA4, Tra1-60, Tra1-81 and Oct3/4 (Fig. 2A), alkaline phosphatase staining (ALP) (Fig. 2B), and qRT-PCR analysis of endogenous pluripotent transcription factors OCT-4, SOX-2, NANOG and REX1 (Fig. 2C). To finally

• br Materials and methods br

  2018-11-12

  

  Materials and methods Results Discussion The main goal of current investigation was to study the role of oxygen in the maintenance of LESC phenotype under conditions of biochemically undefined and a serum-free highly defined growth environment. The oxygen concentrations used in the present

• order W 54011 To investigate whether PD derived HSCs exist i

  2018-11-12

  

  To investigate whether PD-derived HSCs exist in other mammals, we analyzed the resident cells in the peritoneal cavity of C57BL/6 mice without any prior treatment. We found that there was a higher ratio (0.51±0.04%) of Lin−/Sca1+/c-kit+ population in the mouse peritoneal cavity than in bone marrow (

• br Materials and methods The PQ embryos

  2018-11-12

  

  Materials and methods The PQ embryos from in vitro fertilization were donated, and the fetal membranes were collected in accord with the INPER Ethics Committee (212250-21071) as well as the Guidelines for the Conduct of hESC Research (ISSCR, 2006). The hAEC were isolated and cultured from human

• br Introduction The mammary tissue undergoes extensive morph

  2018-11-12

  

  Introduction The mammary tissue undergoes extensive morphological and phenotypic alterations during the pregnancy/lactation cycle forming a complex network of alveolar structures (Rosen et al., 1994; Macias and Hinck, 2012). This cellular architecture exhibits well defined A/B polarization establ

• br Materials and methods br Author disclosure statement br

  2018-11-12

  

  Materials and methods Author disclosure statement Acknowledgments This work was supported by the UK Medical Research Council grants G0701172 and G0801061. We thank Dr. Yacoub Khalaf, Director of the Assisted Conception Unit of Guy\'s and St Thomas\' NHS Foundation Trust and his staff for su

• Dedifferentiation has been considered as

  2018-11-09

  

  Dedifferentiation has been considered as one of the mechanisms rerouting cell fate by reverting differentiated cells to an earlier, more primitive phenotype. Interestingly, previous studies from both our group and others have demonstrated that dedifferentiation is a prerequisite for bone marrow stro

• that does not imply adjusting the step length The convergenc

  2018-11-09

  

  that does not imply adjusting the step length. The convergence process is often sawtooth-shaped and does not always allow finding the solution in an acceptable number of iterations. To remove this difficulty, we analyzed the methods of adjusting the step length in the relation For the case of a

• br Acknowledgment The study has been

  2018-11-09

  

  Acknowledgment The study has been sponsored by a Russian Science Fund grant (project no. 15-19-00091). Introduction The issue of the flow and heat transfer in cross-flowed tube bundles is among the most practically important ‘canonical’ cases [1,2] of the problem on liquid metal coolant ther

• A growing body of literature has developed to formally prese

  2018-11-09

  

  A growing body of literature has developed to formally present these assumptions and discuss their implications for policy makers (Harper et al., 2010). In that spirit, the present analysis seeks to show that efforts to improve overall population health may disadvantage some groups; whether equity o

• In summary the findings from shed new light on

  2018-11-09

  

  In summary, the findings from shed new light on targeted chemotherapy and combinational chemotherapy. The intrinsic properties of different tumor Cyanine3.5 alkyne Supplier may render differential responses to the same treatment. Hence, identifying the heterogeneity within one tumor type is crucial

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