• Subjects occupying the left side of the

  2018-11-09

  

  Subjects occupying the left side of the redesigned decision tree had a low PERSEVERE-based mortality risk. In these subjects, if IL8 decreased by at least 300ng/ml from day 1 to day 3, the probability of a complicated course was 6.3% in the context of a day 1 IL8 concentration ≤525ng/ml (terminal no

• Our survey of the effects of radiation hypoxia and gemcitabi

  2018-11-08

  

  Our survey of the effects of radiation, hypoxia, and gemcitabine on the SP shows that there may not be a consistent effect on this sub-population. This suggests that the SP alone may not be the best method to isolate pancreatic cancer stem cells. Other studies have found that CD24 and ALDH are enric

• In addition to their mesenchymal differentiation capacities

  2018-11-08

  

  In addition to their mesenchymal differentiation capacities, MSCs have a multidirectional differentiation potential including transdifferentiation into endothelial WH-4-023 (Oswald et al., 2004), cardiocytes (Makino et al., 1999), neurocytes (Snykers et al., 2009; Weiss et al., 2006), insulin produ

• Herein we show that NEHUCB CD cell therapy accelerates wound

  2018-11-08

  

  Herein, we show that NEHUCB-CD34+ cell therapy accelerates wound closure in NOD/SCID mice, consistent with previous findings (Barcelos et al., 2009; Kim et al., 2010; Sivan-Loukianova et al., 2003). We used immunocompromised NOD/SCID mice for this study, as this mouse model is often used for human c

• The reversion of somatic cells to pluripotent cells is refer

  2018-11-08

  

  The reversion of somatic e1 activating enzyme to pluripotent cells is referred to as reprogramming. Recently, much of the focus of studies has been on the issue of how to overcome the low reprogramming efficiency (Esteban et al., 2010). Here, we uncovered a new role of JNK-mediated Klf4 phosphoryla

• br Materials and methods br

  2018-11-08

  

  Materials and methods Results Discussion Microglia are resident immune SZL P1-41 in the CNS that regulate innate immunity and participate in adaptive immune response (Hanisch and Kettenmann, 2007). However, the roles of microglia in AD pathology are still under debate. While there is sign

• br Cardiac stem cell niches A challenging

  2018-11-08

  

  Cardiac stem cell niches: A challenging task The importance of the niche microenvironment for understanding HSC behavior was acknowledged shortly after the discovery of this adult stem cell class. In the absence of niches, the stemness of the primitive SR 3576 cannot be preserved. Outside of th

• Chemical library br Materials and methods br

  2018-11-08

  

  Materials and methods Author disclosure statement Acknowledgments We are grateful to Prof. Angel Raya for his help and advice with iPS cell generation. This work was supported by grants from the “Centro de Investigación Biomédica en Red en Enfermedades Raras” (CIBERER) (grant 13-717/132.05

• ikk pathway br Materials and methods br Acknowledgments We

  2018-11-08

  

  Materials and methods Acknowledgments We would like to thank Dr. Keisuke Okita and Prof. Shinya Yamanaka for providing the plasmids for reprogramming. We thank Bente Smith Thorup for excellent technical assistance in the cell culture. We thank Mehri Mirrajei for cytogenetic technical assistanc

• dub inhibitor Although there is strong clinical support for

  2018-11-08

  

  Although there is strong clinical support for developing cellular therapies, and the use of such therapies is already reaching clinical translation (Götherström et al., 2014), ethical issues associated with the collection and use of fetal tissue for research and therapy still remain. Concerned polit

• In our previous studies Choi

  2018-11-08

  

  In our previous studies (Choi et al., 2012; Vodyanik et al., 2006, 2010), we identified distinct stages of hematoendothelial development following hPSC differentiation in coculture with OP9 (Figure 1). Plating hPSCs onto OP9 stromal D-Luciferin induces the formation of primitive streak and mesoderm

• br Methods br Author contribution statement br Competing fin

  2018-11-08

  

  Methods Author contribution statement Competing financial interest Introduction Retinitis pigmentosa (RP) is just one of a group of heterogeneous inherited retinopathies and monogenic disorders that affect thousands of Americans and millions more worldwide (Daiger et al., 2013; Hamel, 20

• Our data are consistent with recent

  2018-11-08

  

  Our data are consistent with recent studies showing that in vivo, transplants of BM flap inhibitor were able to form bone and support marrow formation, while white adipose-derived stromal cells (WAT), cells from umbilical cord (UC), and skin fibroblasts (SF) were not (Kaltz et al., 2008; Reinisch e

• br Introduction Law also known as The Oil Law regulates

  2018-11-07

  

  Introduction Law 9478/97, also known as “The Oil Law,” regulates the collection and sharing of oil rents between the Brazilian federated entities. A significant portion of these rents is distributed to a subset of states and municipalities that must fulfill some requirements, like proximity to pr

• br Grant Support This work

  2018-11-07

  

  Grant Support This work was supported by a research grant from the National Science Council, Taiwan and the Institute of Biomedical Sciences, Academia Sinica (IBMS-CRC103-P02). Conflicts of Interest Author Contributions Introduction Because of late presentation and chemotherapy resistan

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