• A substantial proportion of variants identified familial spo

  2018-10-23

  

  A substantial proportion of variants identified (12.5% familial; 11% sporadic) were not classifiable based solely on RNA analysis as functionally relevant. Nonetheless several of those reported here have been shown to be disease causing by functional analysis and other evidence such as being proven

• On the basis of our genetic findings that hexokinase HK

  2018-10-23

  

  On the basis of our genetic findings that hexokinase 2 (HK2)-mediated aerobic glycolysis, known as the Warburg effect, drives prostate tumor growth in xenograft model bearing /p53-deficient murine or human prostate cancer PI3K Akt mTOR Compound Library (Wang et al., 2014), we designed preclinical s

• Linnman et al reanalyzed the NK receptor data in

  2018-10-23

  

  Linnman et al. (2012) reanalyzed the NK1 receptor data in cWAD patients and healthy controls from an already published study (Linnman et al., 2010). This was done to validate if the NK1 receptor availability was altered in the posterior parietal occipital region as previously reported by others (Lin

• The following are the supplementary data related

  2018-10-23

  

  The following are the supplementary data related to this article. Author Contribution Acknowledgments This study is supported in part by the Bureau of Health Promotion, Department of Health, R.O.C. (Taiwan) (DOH99-HP-1205), Taiwan Ministry of Health and Welfare Clinical Trial and Research Cen

• Invasion of the subarachnoid space by causes a strong

  2018-10-23

  

  Invasion of the subarachnoid space by causes a strong inflammatory cascade orchestrated by the innate immune system involving several receptors like Toll-like receptors (TLR) as well as various cytokines and chemokines (). It is an important question whether genetic variations of the innate immune

• Given that ageing is the

  2018-10-23

  

  Given that ageing is the biggest risk factor for many debilitating diseases that render individuals frail and rob them of their independence and dignity, there are strong moral and economic imperatives to tackle it and prevent the associated pathologies. Newly armed with an idea of how humans age, n

• Specifically in this study the significant

  2018-10-23

  

  Specifically in this study, the significant prediction of metabolic syndrome for ESCC mortality was observed to be largely mediated by hyperglycemia and dyslipidemia. In support of this view, a previous meta-analysis of 17 observational studies documented that males with diabetes may have a modestly

• Overall our findings indicate that smoking is

  2018-10-23

  

  Overall, our findings indicate that smoking is a major driver of molecular heterogeneity in HNSCC, as two HPV− subtypes were clearly more smoking-related, indicated by smoking behavior measures (smoking status, pack years), rates of smoking-related genetic damage (smoking mutation signatures, copy n

• Anti influenza agents are under development because

  2018-10-23

  

  Anti-influenza agents are under development, because antiviral therapy helps reduce the burden of seasonal influenza and provides the first line of defense against pandemic influenza before vaccines are available. Concerns regarding widespread resistance to M2 inhibitors and the emergence of NA inhi

• We profiled AR and MYC binding to

  2018-10-23

  

  We profiled AR and MYC binding to chromatin and found that they co-occupy circa one third of the binding sites. We performed RIME and immunoprecipitation experiments in order to comment on how MYC antagonises AR activity but we did not find evidences of direct interaction between the two transcripti

• Since Tnmd KO mice harbor very mild

  2018-10-23

  

  Since Tnmd KO mice harbor very mild developmental changes, including interesting ultrastructural phenotype characterized by irregular and thicker collagen I fibrils when examined by electron microscopy (Docheva et al., 2005), we hypothesized possible structural and biomechanical alterations of the t

• As for other described cross presentation events

  2018-10-23

  

  As for other described cross-presentation events depending on type I IFN, we can speculate that in the development of this mechanism, APC are able to generate an immune response against soluble EVP-6124 from invading pathogens. This will allow mounting a proper cellular killing arm of defense for n

• br Data Cross linking formaldehyde and denaturing ethanol

  2018-10-23

  

  Data Cross-linking (formaldehyde) and denaturing (70% ethanol and methanol/glacial acidic acid, 3:1, v/v) fixatives exert different effects on oocyte and NLB morphology (Fig. 1a, a′, a″), large-scale chromatin configuration (b, b′, b″) and on accessibility of the NLB material to immunofluorescenc

• br Experimental design materials and

  2018-10-23

  

  Experimental design, materials and methods X-ray diffraction datasets were collected at synchrotron beamlines ID23-1 [2] (ESRF) and XALOC [3] (ALBA), from flash cooled (in liquid nitrogen) single crystals and kept under nitrogen gas during data collection. Diffraction data already reduced and sca

• The flood prone areas maps have been

  2018-10-23

  

  The flood-prone areas maps have been derived applying a technique of pattern recognition through computational learning. Starting from morphological attributes of a basin, embodied in the Geomorphic Flood Index, a linear binary classifier was built and used to delineate flood-prone areas according t

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