• To further implicate the role of EAAT in morphine

  2022-01-26

  

  To further implicate the role of EAAT3 in morphine-induced place preference, the effects of morphine on EAAT3 XL413 hydrochloride receptor was determined. Interestingly, morphine increased EAAT3 protein expression in the plasma membrane of mPFC, nucleus accumbens and VTA but not in the hippocampus

• Z-Ligustilide Transmembrane AMPA receptor regulatory protein

  2022-01-26

  

  Transmembrane AMPA receptor regulatory proteins (TARPs) are a relatively newly discovered protein family. Prototypic TARP, stargazin, was found by a spontaneous mutation in ataxic stargazer mouse line as a homologous protein to γ1 calcium channel subunit (Letts et al., 1998). The role of stargazin i

• br Materials and methods br Conflicts of interest Some of

  2022-01-26

  

  Materials and methods Conflicts of interest Some of the peptidomimetic compounds in this work are the subject of the patent application “Peptidomimetics for Imaging the Ghrelin Receptor”, WO/2016/191865 A1, December 8th, 2016. Acknowledgements Special thanks go to Rebecca McGirr (Lawson He

• br Materials and methods br Chemical

  2022-01-26

  

  Materials and methods Chemical synthesis Declaration of interest Acknowledgements This research was supported by a grant from the National Institute for General Medicine to K.W.M. (GM 58448) and by the Department of Anesthesia, Critical Care & Pain Medicine at Massachusetts General Hospi

• An advantage of photolabeling with tritiated photoprobes fol

  2022-01-26

  

  An advantage of photolabeling with tritiated photoprobes followed by microsequencing with Edman degradation is the ability to both identify the photolabeled LB Broth, Miller and to quantify photoincorporation which enables assessment of pharmacological specificity and allosteric interactions with o

• FXR agonists represent an attractive class of drugs for

  2022-01-26

  

  FXR agonists represent an attractive class of drugs for patients with PFIC. Synthetic and semi-synthetic FXR agonists, with higher affinity and potency to activate FXR, have been successfully tested in animal models of cholestasis. In these murine models, the semi-synthetic steroidal FXR ligand obet

• Canonical and non canonical Wnt

  2022-01-26

  

  Canonical and non-canonical Wnt signaling pathways play essential roles in various cellular activities, including cell fate determination, proliferation, migration and gene expression [57]. The canonical Wnt pathway (β-catenin dependent pathway), is activated by the binding of Wnt ligands, leading t

• The subcellular redistribution of some metabolic enzymes is

  2022-01-26

  

  The subcellular redistribution of some metabolic enzymes is dynamic and responsive to metabolic conditions. In the absence of glucose, Glucokinase (GK) is bound to its regulatory protein in the nucleus of the hepatocyte and translocates to the cytoplasm when sugar levels increase [12]. Muscle glycog

• The newly synthesized compounds were

  2022-01-26

  

  The newly synthesized compounds were evaluated for their FAAH inhibitory activity in vitro. In addition, molecular modeling, selectivity and reversibility behavior of the new class of FAAH inhibitors are presented in this article. Results and discussion The potency of inhibition on the human rec

• As concerns TRPV assays benzylic

  2022-01-26

  

  As concerns TRPV1 assays, benzylic amides and benzylic reverse amides exhibited an overall superiority over their aryl counterparts and , and ureas and . A reversed trend was however observed with the 4-chlorostyryl and 4--butylphenyl moieties (compare compounds and ; , , and ; and ). The EC and IC

• br The inhibitory effect of ATP B knockdown on lysosomal

  2022-01-26

  

  The inhibitory effect of ATP7B knockdown on lysosomal exocytosis is likely mediated by the resulting oxidative stress induced by Cu, as exposure to oxidative stress induced by tert-Butyl hydroperoxide (TBHP) inhibited β-hex exocytosis as well, indicating that oxidative stress inhibits lysosomal ex

• br TGR agonists current developments and

  2022-01-26

  

  TGR5 agonists: current developments and future landscape The amphipathic nature of bile acids is crucial in aiding the digestion and GFP Quantitation Kit mg of vitamins and fats. With the emerging roles of bile acids in the regulation of energy and glucose homeostasis through TGR5, the pharmaceut

• Acarbose and voglibose the classic glucosidase inhibitors we

  2022-01-25

  

  Acarbose and voglibose, the classic α-glucosidase inhibitors, were clinically used to inhibit α-glucosidase activity for the treatment of type 2 diabetes. However, the intake of these drugs may cause some undesirable gastrointestinal side effects and weight gain (Xu et al., 2015). The synthetic drug

• br Phylogenetic analysis of vertebrate receptors for peptide

  2022-01-25

  

  Phylogenetic analysis of vertebrate receptors for peptides similar to glucagon Genes for receptors for peptides similar to glucagon and other secretin-like hormones have been identified in a number of vertebrate species (Sivarajah et al., 2001, Chow et al., 2004, Irwin and Wong, 2005, Cardoso et

• In the absence of HH ligand

  2022-01-25

  

  In the absence of HH ligand, HH signaling is actively maintained in a repressed state by the activity of the HH receptor Patched (PTCH). PTCH is a 12-transmembrane domain protein whose intracellular localization is concentrated at the Vinpocetine of the primary cilium, a single antenna-like structur

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